Yeup. Series 5 too, since the story both begins and ends there. I remember thinking as far back as ToA/FaS, when Eleven starts talking about how time can be rewritten, "there are gonna be huge consequences for that, buddy".
Oh absolutely (just like Ten's downfall built up piece by piece). And ToA/FaS isn't just the first appearance of 'Time can be rewritten' but also of 'What if time could run out?' (Darn Moffat is good.)

Also Ten's crotch is glowing... tee hee /immature
That's because he is radioactive! \o/